abstract：:Of 476 patients with multiple myeloma treated during a 9-year period, 11 developed acute myelogenous leukemia or sideroblastic anemia. In all, the myeloma was in remission from chemotherapy with melphalan-prednisone combinations that had been continued for a median duration of 3 years. The incidence of acute leukemia ...

journal_title：Annals of internal medicine

authors： Gonzalez F,Trujillo JM,Alexanian R

更新日期：1977-04-01 00:00:00

abstract：:Severe pulmonary hypertension without pulmonary fibrosis occurred in 10 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia), reputedly a benign variant of progressive systemic sclerosis. Time from the initial symptom, Raynaud's phenomenon, to the r...

journal_title：Annals of internal medicine

authors： Salerni R,Rodnan GP,Leon DF,Shaver JA

更新日期：1977-04-01 00:00:00

abstract：:In a double-blind study of four patients with hereditary angioedema, the efficacy of methyltestosterone (taken daily in 10-mg linguet form) in preventing attacks was shown. There were 19 episodes during 11.8 months of placebo administration, compared with only four attacks during the 46 months of cumulative methyltest...

journal_title：Annals of internal medicine

authors： Sheffer AL,Fearon DT,Austen KF

更新日期：1977-03-01 00:00:00

abstract：:The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasm...

journal_title：Annals of internal medicine

authors： Schnur MJ,Appel GB,Karp G,Osserman EP

更新日期：1977-03-01 00:00:00

abstract：:The association of the Epstein-Barr virus and two human malignancies, Burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. ...

journal_title：Annals of internal medicine

authors： Ziegler JL,Magrath IT,Gerber P,Levine PH

更新日期：1977-03-01 00:00:00

abstract：:A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test finding...

journal_title：Annals of internal medicine

authors： Sbarbaro JA,Bennett RM

更新日期：1977-02-01 00:00:00

abstract：:Between 20 July and 15 Octoboer 1975, five cases of human infection with Babesia microti were diagnosed on Nantucket Island, Massachusetts. The illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. None of the patients had a...

journal_title：Annals of internal medicine

authors： Reubush TK 2nd,Cassaday PB,Marsh HJ,Lisker SA,Voorhees DB,Mahoney EB,Healy GR

更新日期：1977-01-01 00:00:00

abstract：:Adult salicylate intoxication has been considered to be easily recognized and assciated with low morbidity and mortality. In the present study of 73 consecutive adults hospitalized with salicylate intoxication, 27% of patients were undiagnosed for as long as 72 h after admission. The initial physical findings and labo...

journal_title：Annals of internal medicine

authors： Anderson RJ,Potts DE,Gabow PA,Rumack BH,Schrier RW

更新日期：1976-12-01 00:00:00

abstract：:The youthful habits and family attitudes of medical students who later developed or died from one of five disease states were different from those of healthy classmate controls to begin with. In medical school, the total disorder group had significantly more nervous tension, anxiety, and anger under stress, had more i...

journal_title：Annals of internal medicine

authors： Thomas CB

更新日期：1976-11-01 00:00:00

abstract：:Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

journal_title：Annals of internal medicine

authors： Johnson RH,Lutwick LI,Huntley GA,Vosti KL

更新日期：1976-11-01 00:00:00

abstract：:An investigation of patient care in four hospitals compared levels of resource use between 1964 and 1974 for patients with a primary diagnosis of pneumonia. Results showed a decreased length of stay in all hospitals. Unique patterns of increases and decreases existed in each hospital for the changing use of diagnostic...

journal_title：Annals of internal medicine

authors： Sheeley DR,Sherman H

更新日期：1976-11-01 00:00:00

abstract：:HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous...

journal_title：Annals of internal medicine

authors： Russell AS,Lentle BC,Percy JS,Jackson FI

更新日期：1976-11-01 00:00:00

abstract：:Our review focuses on low density lipoprotein (LD lipoprotein) and very low density lipoprotein (VLD lipoprotein) in their roles as transporters of cholesterol and triglyceride and as factors contributing to premature arteriovascular disease. We describe the clinical manifestations of the common, primary hyperlipoprot...

journal_title：Annals of internal medicine

authors： Fisher WR,Truitt DH

更新日期：1976-10-01 00:00:00

abstract：:The relation of menopause to cardiovascular disease incidence was examined in women less than 55 years old from the cohort of 2873 women in the initial Framingham examination. Although the number of person-years of experience during the 20 years of observation was nearly the same for premenopausal and postmenopausal s...

journal_title：Annals of internal medicine

authors： Kannel WB,Hjortland MC,McNamara PM,Gordon T

更新日期：1976-10-01 00:00:00

abstract：:Aspirin breaks the gastric mucosal barrier. We studied the effect of aspirin on this barrier, correlating changes in potential difference and ultrastructure. Mean control potential difference for seven subjects was -48 +/- 1.0 mV. Oral aspirin, 600 mg in 100 ml of saline, reduced potential difference to -39 +/- 1.4 mV...

journal_title：Annals of internal medicine

authors： Baskin WN,Ivey KJ,Krause WJ,Jeffrey GE,Gemmell RT

更新日期：1976-09-01 00:00:00

abstract：:Enlargement of the pituitary gland associated with primary hypothyroidism was observed in two patients. Serum thyroid-stimulating hormone (TSH) concentration and the TSH response to thyrotropin-releasing hormone were increased in both. Other pituitary function tests were subnormal in both patients, suggesting that a t...

journal_title：Annals of internal medicine

authors： Vagenakis AG,Dole K,Braverman LE

更新日期：1976-08-01 00:00:00

abstract：:Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function have been described in uncomplicated influenza A. To study the effect of amantadine on these changes, we evaluated young adults with documented natural influenza A with clear chest...

journal_title：Annals of internal medicine

authors： Little JW,Hall WJ,Douglas RG Jr,Hyde RW,Speers DM

更新日期：1976-08-01 00:00:00

abstract：:Plasma lipids were measured in 78 uremic patients receiving either chronic peritoneal dialysis or haemodialysis. Type IV hyperlipemia was found in 60% of patients. The lipid level was not influenced by dietary habits or patient's age. Patients on chronic peritoneal dialysis had a significantly higher and more sustaine...

journal_title：Annals of internal medicine

authors： Cattran DC,Fenton SS,Wilson DR,Steiner G

更新日期：1976-07-01 00:00:00

abstract：:Multiple myeloma raises a number of puzzling questions about the production of immunoglobulins and the malignant transformation of lymphoid cells. Some of these questions can be approached by studying mouse plasmacytomas and by genetic and biochemical studies of mouse myeloma cells in culture. The synthesis, assembly,...

journal_title：Annals of internal medicine

authors： Weitzman S,Margulies DH,Scharff MD

更新日期：1976-07-01 00:00:00

abstract：:A 45-year-old woman from Mendoza, Argentina, was severely bitten by a dog that died 4 days later. Before death, the dog was nervous, aggressive, and had occasional seizures. Ten days after the woman had been bitten, rabies vaccine treatment was begun: 14 daily doses of suckling mouse brain vaccine followed by 2 booste...

journal_title：Annals of internal medicine

authors： Porras C,Barboza JJ,Fuenzalida E,Adaros HL,Oviedo AM,Furst J

更新日期：1976-07-01 00:00:00

abstract：:Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver dis...

journal_title：Annals of internal medicine

authors： Cederbaum AI,Blatt PM,Roberts HR

更新日期：1976-06-01 00:00:00

abstract：:Chronic lymphocytic leukemia developed in four of five siblings, whose father succumbed to the same disease. The pattern of immune deficiency in the leukemic siblings resembled that found in nonfamilial cases of chronic lymphocytic leukemia, and was correlated with the severity of clinical involvement. In three siblin...

journal_title：Annals of internal medicine

authors： Blattner WA,Strober W,Muchmore AV,Blaese RM,Broder S,Fraumeni JF Jr

更新日期：1976-05-01 00:00:00

abstract：:One half of 42 subjects treated for painful shoulders received classic acupuncture, and one half received a placebo in which the needles did not penetrate the skin. Half of each of these groups was treated in a positive setting to encourage the subject, and half in a negative setting designed to keep encouragement at ...

journal_title：Annals of internal medicine

authors： Moore ME,Berk SN

更新日期：1976-04-01 00:00:00

abstract：:The prevalence of active tuberculosis and positive tuberculin skin tests was assessed in 132 corticosteroid-treated asthmatics for an evaluation period that represented 620 corticosteroid-years of therapy. There was no evidence of active tuberculosis in any of these patients. Positive intermediate-strength tuberculin ...

journal_title：Annals of internal medicine

authors： Schatz M,Patterson R,Kloner R,Falk J

更新日期：1976-03-01 00:00:00

abstract：:Polysaccharide vaccines against diseases caused by Neisseria meningitidis serogroups A and C meningococci are now licensed in the United States. They are prepared as monovalent and as bivalent antigens. This statement summarizes available information on these antigen and offers guidance regarding their role in the con...

journal_title：Annals of internal medicine

authors：

更新日期：1976-02-01 00:00:00

abstract：:Nine of 81 members of two families were found to have renal problems. Three patients in one family had renal-retinal dysplasia with probable recessive inheritance. Of the 6 patients in the second family, one received a kidney transplant from his brother who initially had no detectable renal abnormality but later devel...

journal_title：Annals of internal medicine

authors： Avasthi PS,Erickson DG,Gardner KD

更新日期：1976-02-01 00:00:00

abstract：:Sixty-nine out of a kindred of 100 members covering five generations were examined and studied, and 34 were hypercalcemic. Sixteen subjects were believed, on the basis of laboratory and clinical observations, to have primary hyperparathyroidism. Eight patients were subjected to exhaustive study to identify polyendocri...

journal_title：Annals of internal medicine

authors： Goldsmith RE,Sizemore GW,Chen IW,Zalme E,Altemeier WA

更新日期：1976-01-01 00:00:00

abstract：:From 1969 to 1974, 19 cases of Serratia marcescens endocarditis were observed in the San Francisco Bay Area. Seventeen patients were intravenous drug users, and Serratia caused 14% of all addict-associated endocarditis in San Francisco. Serratia strains were nonpigmented and had typical antibiotic sensitivities, excep...

journal_title：Annals of internal medicine

authors： Mills J,Drew D

更新日期：1976-01-01 00:00:00

abstract：:Five patients with chronic renal failure who were undergoing maintenance hemodialysis developed a self-limited bullous dermatosis restricted to light exposed areas, primarily involving the dorsa of the hands. Porphyrin levels and phototesting were normal, but histologic sections of the bullae showed thickening of venu...

journal_title：Annals of internal medicine

authors： Gilchrest B,Rowe JW,Mihm MC Jr

更新日期：1975-10-01 00:00:00

abstract：:Thirty-five consecutives patients with classic or definite rheumatoid arthritis underwent echocardiography to evaluate the motion of the anterior mitral valve leaflet. Adequate echocardiograms were obtained in 31 patients. All 31 patients showed normal valve motion and a normal EF slope. If meticulous technique was no...

journal_title：Annals of internal medicine

authors： Davia JE,Cheitlin MD,de Castro CM,Lawless O,Niemi L

更新日期：1975-10-01 00:00:00

abstract：:Since 1969, medications have been provided to patients at the Johns Hopkins Hospital using a computer system that controls the entire medication process from entry of physician's order to hourly drug distribution. Special envelopes containing patient and dosage information are computer generated for each dose to be ad...

journal_title：Annals of internal medicine

authors： Simborg DW,Derewicz HJ

更新日期：1975-09-01 00:00:00

abstract：:The sharp rise in drug abuse in the past decade has led to the development of new sources of information on drug-abuse trends. These include surveys, drug-related emergencies, drug-abuse treatment, hepatitis rates, and various types of law enforcement information. This paper summarizes data currently available for her...

journal_title：Annals of internal medicine

authors： Greene MH,Nightingale SL,DuPont RL

更新日期：1975-09-01 00:00:00

abstract：:Thyroid antibodies were found significantly more often in insulin-dependent diabetics than in their spouses or in non-insulin-dependent diabetics. The poor correlation between presence of thyroid autoimmunity and duration of disease and the significantly increased prevalence of thyroid antibodies in first-degree relat...

journal_title：Annals of internal medicine

authors： Fialkow PJ,Zavala C,Nielsen R

更新日期：1975-08-01 00:00:00

abstract：:We discuss here some of the last decade's diagnostic and therapeutic advances in the treatment of lung cancer, as well as current and future research objectives. Roentgenographs from selected patients illustrate the natural history of lung cancer. We present perspectives concerning selection from the growing diagnosti...

journal_title：Annals of internal medicine

authors： Benfield JR,Julliard GJ,Pilch YH,Rigler LG,Selecky P

更新日期：1975-07-01 00:00:00

abstract：:Two cases of patients having calcification within the sella turcica (pituitary stones) have been studied and followed up, one patient for 18 years. A detailed analysis of the radiographic findings and endocrinologic profiles of these two patients is presented. The rarity of bona fide pituitary stones and their benign ...

journal_title：Annals of internal medicine

authors： Di Chiro G,Saldino R,McGuffin WL Jr,Sachson RA,Gorden P,Bartter FC

更新日期：1975-07-01 00:00:00

abstract：:Eight patients developed grand mal seizures during intravenous theophylline therapy. None had a history of neurologic disorder, and all were acutely ill with severe pulmonary or cardiovascular disease, or both. Serum theophylline concentrations obtained within 1 hour of the seizure ranged from 25 mug/ml to 70mug/ml, w...

journal_title：Annals of internal medicine

authors： Zwillich CW,Sutton FD,Neff TA,Cohn WM,Matthay RA,Weinberger MM

更新日期：1975-06-01 00:00:00

abstract：:Young adults with cystic fibrosis have lower blood pressures than control subjects of similar age and sex. The low blood pressure may be related to the excessive loss of salt in the sweat of these patients. A beneficial effect of the cystic fibrosis gene may be protection against developing hypertension in both the ho...

journal_title：Annals of internal medicine

authors： Lieberman J,Rodbard S

更新日期：1975-06-01 00:00:00

abstract：:The coexistence of pregnancy and idiopathic hypertrophic subaortic stenosis is a potentially dangerous combination. We report a 23-year-old white woman with idiopathic hypertrophic subaortic stenosis and pregnancy who presented with severe symptoms (Class IV) and modest outflow obstruction associated with marked mitra...

journal_title：Annals of internal medicine

authors： Kolibash AJ,Ruiz DE,Lewis RP

更新日期：1975-06-01 00:00:00

abstract：:An unusual cluster of 11 patients with Pneumocystis carinii pneumonia occurred in a 3-month period at Memorial Hospital, New York. Ten of the 11 patients had lymphoma or leukemia. In 7 patients, corticosteroid therapy was decreased or stopped shortly before pneumocystis pneumonia was diagnosed. The pediatric patients ...

journal_title：Annals of internal medicine

authors： Singer C,Armstrong D,Rosen PP,Schottenfeld D

更新日期：1975-06-01 00:00:00

abstract：:Two patients developed severe hypomagnesemia, hypocalcemia, and hypokalemia as a result of renal wasting of magnesium and potassium shortly after being treated with large doses of gentamicin. When therapy with gentamicin was discontinued renal loss of magnesium and potassium ceased, and serum calcium, magnesium, and p...

journal_title：Annals of internal medicine

authors： Bar RS,Wilson HE,Mazzaferri EL

更新日期：1975-05-01 00:00:00